CLAM-2030 - 應用資訊

CLAM-2030 全自動LCMS前處理系統

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Paper 文件

Masuda J. and Kato Y.:

使用液相層析串聯質譜儀同時分析人類血液中的Raltegravir、Dolutegravir、Elvitegravir和Bictegravi。
Showa Univ J Med Sci. 32 (1), 91-102, 2020.

http://dx.doi.org/10.15369/sujms.32.91

Robin T., Saint-Marcoux F., Toinon D., Tafzi N., Marquet P., El Balkhi S.:

自動化定量血液中的uracil和dihydrouracil。
J Chromatogr B: 1142, 2020.

http://dx.doi.org/10.1016/j.jchromb.2020.122038

Robin T.,Barnes A.,Dulaurent S.,Loftus N.,Baumgarten S.,Moreau S.,Marquet P.,El Balkhi S.,Saint-Marcoux F.:

使用全自動樣品前處理-液相層析串聯質譜儀分析血液中的濫用藥物。
Anal Bioanal Chem., 410: 5071-5083, 2018.

http://dx.doi.org/10.1007/s00216-018-1159-7

Nishiumi S, Shima K, Azuma T, Yoshida M.:

用於評估親水性血液代謝物的新分析系統。
J Biosci Bioeng, 123:754-759, 2017.

http://dx.doi.org/10.1016/j.jbiosc.2017.01.015

Shimadzu Review

Shimadzu Review 74 [1・2] 11~17 (2017.9)	通過全自動樣品前處理 LC/MS/MS 系統分析血清中的 25-OH 維生素 D2/D3 和類固醇使用LC/MS/MS對血清等生物樣品進行分析時，需要執行蛋白質沉澱和樣品稀釋等前處理。這些過程可能會因為操作員對於操作流程的經驗不足而導致變化和錯誤。本文介紹了使用LC/MS/MS 全自動樣品製備系統來檢驗血清中的 25-OH 維生素 D2/D3 和類固醇。

通過全自動樣品前處理 LC/MS/MS 系統分析血清中的 25-OH 維生素 D2/D3 和類固醇
使用LC/MS/MS對血清等生物樣品進行分析時，需要執行蛋白質沉澱和樣品稀釋等前處理。這些過程可能會因為操作員對於操作流程的經驗不足而導致變化和錯誤。本文介紹了使用LC/MS/MS 全自動樣品製備系統來檢驗血清中的 25-OH 維生素 D2/D3 和類固醇。

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CLAM 應用資訊

下列為使用CLAM模組的應用範例。

應用	目標化合物	備註
抗癲癇藥	Levetiracetam, Felbamate, Topiramate,Carbamazepine10-11-epoxide, Carbamazepine(CBZ), Tiagabine, Diazepam, Gabapentin, Pregabalin, PEMA, Lacosamide, Primidone, CBZ-Diol, Lamotrigine, 10-OH-CBZ, Rufinamide, Oxacarbazepine, Phenytoin, Perampanel, Retigabine, Stiripentol, Ethosuximide, Sultiame, Valpronic acid, Zonisamide, Phenobarbital, NDMS	Application News NO.C123
抗心律失常藥物	Amiodarone, n-Desethylamiodarone, Sotalol, Bepridil, Flecainide, Pilsicainide, Cibenzoline, Mexiletine	Application News NO.C153
免疫抑制劑	Cyclosporin A, Tacrolimus (FK 506), Rapamycin (Sirolimus), Everolimus, Mycophenoloc acid(MPA), Mycopenolic acid glucuronide(MPA-G)	Maki Takane et al: transplantation, 65 (1) (2021) Technical Report (C297-0526)
Antibacterial drugs	Ciprofloxacin, Levofloxacin, Linezolid, Vancomycin, Gentamicin, Streptomycin, Amikacin, Teicoplanin, Daptomycin, Kanamycin, Neomycin B,Paromycin, Hygromycin C, Arbekacin
抗真菌藥	Voriconazole
抗凝藥物	DOACs (Apixaban, Rivaroxaban, Edoxaban, Dabigatran), Acenocoumarol,Betrixaban,Fluindione, Warfarin	Daisuke Kawakami: Precision Medicine, 1(2) (2018) PO-CON1602E
抗癌藥	5-FU（uracil and dihydrouracil）	Robin T., et al.: J Chromatogr B, 1142 (2020)
類固醇	Aldosterone, Cortisol, DHEA-S,Corticosterone, 17-OH-Progesterone, Progesterone, DHEA, Teststerone,Androstenedion,11-Deoxycortisol	PO-CON1691E Shimadzu Review, 74(1･2): 11~17 (2017)
Vitamin D	25-hydroxyvitamin D2, 25-hydroxyvitamin D3	PO-CON1692E PO-CON1826E Shimadzu Review, 74(1･2): 11~17 (2017)
維生素 B1、B6	Thiamin Pyrophosphate(TPP), Pyridoxal-5’-Phoshate(PLP)
維生素 A	維生素 A
變腎上腺素	Metanephrin, normetanephrine
抗病毒藥物	HIV：Integrase inhibitor（DTG、EVG、RAL、BIC） COVID-19 :Remdesivir and GS-441524, Favipiravir 　　　　Dexamethasone and antibiotics(Tazobactam, Meropenem,Piperacillin)	Shimadzu Review, 77(1･2) (2020) Application News NO. C217, C230, and other
代謝體學	Primary metabolites	Nishiumi S et al., J Biosci Bioeng., 123(6) (2017) Application News No. C150
抗精神病藥物	Aripiprazole, Clopazine, Dehydroaripiprazole, Desmethylclopazine, Haloperidol, N-Desmethylolanzapine, Norquetiapine, Olanzapine, Quetiapine, Risperidone, 9-OH-Risperidone, Amisulpride, Levomepromazine, Melperone, Perazine, Pipamperone, Promethazine, Sertindole, Sulpiride, Thioridazine, (Z)-Chorprothixene, Ziprasidone, Zotepine, Zuclopenthixol	IATDMCT_poster Neuroleptics
Drug of abuse(DOA)	2-Cl, 2C-B, 3,4-Methylenedioxypyrovalerone, 4-MTA, 6-acetylmorphine, 6-MAM,Amphetamine, Anhydroecgonine methyl ester, BDB, Benzoylecgonine, Buprenorphine, Cocaethylene, Cocaine, Codeine, Dextromethorphan, Dihydrocodeine, Ecgonine methylester, EDDP, Ethylmorphine, Hydrocodone, Hydoromorphone, Ketamine, MBDB, m-CPP, MDA, MDEA, MDMA, Mephedrone, Methadone, Methamphetamine, Methaqualone, Methcathinone, Methiopropamine, Methylphenidate, Morphine, Naloxone, Naltrexone, Nimetazepam, Norbuprenorphine, Norephedrine, Norfenfluramine, Norketamine Noroxycodone, Norpseudoephedrine, Oxycodone, Phencyclidine, Pholcodine, Propoxyphene, Ritalinic acid	Robin T., et al.:Anal Bioanal Chem., 410(20):5071-5083 (2018)
藥用毒物	8 Barbiturate drug and Bromovalerylurea, 12 Tri-/Tetra-cyclic antidessant, 39 Benzodiazepines and their metamolites

僅供研究使用。不用於診斷過程。