LC/MS/MS 快速毒理學快篩系統 Ver.3

LC/MS/MS Rapid Toxicology Screening System

毒物學常見的 231 種化合物資料庫

此系統可讓使用者直接上機進行分析，不需要經過方法開發的耗時步驟 (例如分離條件和 MS 參數最佳化)，進而提高了 LC/MS/MS 分析方法的效率。
針對 231 種化合物(包括濫用藥物、精神神經藥物和鎮靜劑)且分析時間少於 15 分鐘快速同步分析方法。此系統提供 synchronised survery scan 最佳化條件 (透過 MRM 圖譜強度閾值啟動子離子圖譜收集；MRM triggered product ion scanning)。

半定量的完整解決方案

方法中的每個化合物，都有相對應內標的標準曲線資訊，因此可以在分析後獲得的半定量之數值。QuEChERS 方法^*的前處理方法，可以讓待測物從生物樣品中被萃取出來因而獲得良好的回收率。而在資料處理部分可使用光譜資料庫進行定性分析。換言之，此系統提供了包括前處理、上機分析條件和資料處理及判讀的整體解決方案。

使用 Micro Volume QuEChERS 試劑組進行前處理

>> *請參閱詳細前處理步驟

使用 LabSolutions Insight Library Screening 進行數據分析的範例：

使用 LabSolutions Insight Library Screening，您可以獲得以下之數據：

(1) 定量結果
(2) 資料庫檢索結果
(3) MS 層析圖
(4) MS/MS 譜圖
(5) 結構式

化合物清單列表：

231 種化合物，其中包含真實案例相關的非法藥物、鎮靜劑、精神藥物和醫療藥物。

IS Diazepam-D5（Positive）
IS_Phenobarbital-D5 (negative)
7-Aminoclonazepam
7-Aminoflunitrazepam
7-Aminonimetazepam
7-Aminonitrazepam
8-Hydroxyetizolam (M-III)
Acetaminophen
Aconitine
Alfa-methyltryptamine
Allylisopropylacetylurea
alpha-Hydroxyalprazolam
alpha-Hydroxymidazolam
alpha-Hydroxytriazolam
Alprazolam
Amitriptyline
Amlodipine
Amobarbital
Amoxapine
Amphetamine
Ampicillin
Aripiprazole
Atenolol
Atomoxetine
Atorvastatin
Atropine
Azelnidipine
Azilsartan
Barbital
Benzoyl ecgonine
Biperiden
Blonanserin
Brexpiprazole
Bromazepam
Bromocriptine
Bromovalerylurea
Bromperidol
Brotizolam
Bupivacaine
Caffeine
Candesartan
Carbamazepine
Carbazochrome
Carpipramine
Carvedilol
Chlordiazepoxide
Chlorpheniramine
Chlorpromazine

Chlorpromazine-M (bis-nor-)
Cibenzoline
Clobazam
Clocapramine
Clomipramine
Clonazepam
Clotiazepam
Cloxazolam
Clozapine
Cocaine
Codeine
Colchicine
DDVP
Delorazepam
DEP
Desipramine
Desmethylclotiazepam
Desmethyldiazepam
Dextromethorphan
Diazepam
Dibucaine
Diclofenac
Dihydrocodeine
Diltiazem
Diphenhydramine
Diprophyline
Diquat
Domperidone
Donepezil
Dosulepin
Droperidol
Duloxetine
Ecgonine methyl ester
Ephedrine
Escitalopram
Estazolam
Ethenzamide
Ethyl loflazepate
Etizolam
Famotidine
Fludiazepam
Flufenamic acid
Flunitrazepam
Fluphenazine
Flurazepam
Fluvoxamine
Furosemide

Gabapentin
Glibenclamide
Gliclazide
Glimepiride
Haloperidol
Haloxazolam
Hydroxymethylbrotizolam
Hydroxyzine
Ibuprofen
Imidapril
Imipramine
Irbesartan
Isopropylantipyrine
Ketamine
Ketoprofen
Lamotrigine
Levetiracetam
Levomepromazine
Lidocaine
Lorazepam
Lormetazepam
Losartan
Loxoprofen
Malathion
Maprotiline
MDA
MDMA
Medazepam
Mefenamic acid
Memantine
Mepivacaine
Mequitazine
Metformin
Methamphetamine
Methomyl
Methylephedrine
Methylphenidate
Mexazolam
Mexiletine
Mianserin
Midazolam
Milnacipran
Mirtazapine
Morphine
Mosapramine
Naftopidil
N-Desmethyl clobazam

N-Desmethyl zopiclone
N-Desmethylmirtazapine
Nemonapride
Nicardipine
Nicotine
Nicotine-M
Nifedipine
Nimetazepam
Nitrazepam
Norephedrine
Nortriptyline
Noscapine
Olanzapine
Olmesartan
Oxazepam
Oxypertine
Paliperidone
Papaverine
Paroxetine
Pemoline
Pentazocine
Pentobarbital
Perospirone
Perphenazine
Phenobarbital
Phenytoin
Pimozide
Pioglitazone
Pipamperone
Piroxicam
Pitavastatin
Pranlukast
Primidone
Procaine
Prochlorperazine
Promethazine
Propericiazine
Propofol
Propranolol
Quazepam
Quetiapine
Risperidone
Ropivacaine
Rosuvastatin
Salicylamide
Salicylic acid

Secobarbital
Sertraline
Setiptiline
Sildenafil
Silodosin
Sitagliptin
Solifenacin
Spiperone
Spironolactone
Sulfamethoxazole
Sulpiride
Sultopride
Suvorexant
Tadalafil
Tandospirone
Telmisartan
Temazepam
Tetracaine
THC
THC-COOH
Thiamylal
Timiperone
Tofisopam
Topiramate
Tramadol
Trandolapril
Trazodone
Triazolam
Trihexyphenidyl
Trimethoprim
Trimipramine
Urapidil
Valproic Acid
Valsartan
Vardenafil
Venlafaxine
Verapamil
Warfarin
Zalepron
Zolpidem
Zolpidem _M-1
Zonisamide
Zopiclone
Zopiclone-N-oxide
Zotepine

備註及注意事項

LabSolutions LCMS 版本需為 5.109 或更新版本，而 LabSolutions Insight Ver. 3.8SP1 或更新版本。
根據所用設備的條件和實際情況，可能會出現定量值的差異。要獲得準確的定量值，請使用合適標準樣品的校正曲線方法。此外，在資料庫中搜尋得到的分數說明圖譜的相似性，是鑑別化合物的其中一個依據；但要更準確鑑別化合物，結合滯留時間和樣品資訊等會更有效率。

LabSolutions 為 Shimadzu Corporation 其在日本或其他國家分公司的商標。

僅供研究使用，不能用於診斷程序。

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